Formulation, invitro and invivo analysis of cyclodextrin complexed albendazole composites for enhanced solubility
نویسندگان
چکیده
منابع مشابه
Enhancement of Solubility of Albendazole by Complexation with -cyclodextrin
A high dosage of albendazole (ABZ) is required for treating systemic helminthe infections because of its low solubility. Aiming at increasing ABZ solubility, complexation with beta-cyclodextrin ( -CD) using aqueous and acetic acid solutions as ABZ solubilizer was studied. In aqueous -CD, complexation increased solubility 53.4 times, giving a complex equilibrium constant of 1266 L mol with a max...
متن کاملSuper Aqueous Solubility of Albendazole in β-Cyclodextrin for Parenteral Application in Cancer therapy
Poor aqueous solubility of anticancer drug, albendazole (ABZ), prevents parenteral application. Here, we demonstrate how to increase the aqueous solubility of ABZ to 6- 8 mg/ml using sulfobutylether - β-cyclodextrin (SBE-β-CD) or Hydroxypropyl- β-cyclodextrin (HP- β-CD) by manipulation of complexation parameters such as the physical state of ABZ (ionized in acetic acid), the concentration of io...
متن کاملAlbendazole-cyclodextrin complex: enhanced cytotoxicity in ovarian cancer cells.
BACKGROUND Over recent years, we have identified a potentially new indication for albendazole (ABZ) namely that of an anticancer agent. Our recent data indicate that besides regional use, the drug is quite likely to be useful as a systemic anticancer agent. However, with extremely low solubility, ABZ has to be prepared in a biocompatible solubilized form before any systemic evaluation is possib...
متن کاملElectrochemical, invivo and invitro study of Acyclovir and Co(II) Complex
The antibiotic drug 2-amino-1,9-dihydro-9-(2-hydroxyethoxy)methyl)-6H-purin-6-one has been quantitatively and qualitatively analysis by polarographic & amperometric process. Acyclovir give well identified wave in 1.0mkcl at pH5.0±0.2.Co (II)-Acyclovir complex studied in aqueous phase..The IR spectral data on the drug & its Co (II) complex indicate the co-ordination through nitrogen atom of azid...
متن کاملFormulation and Evaluation of Self microemulsifying drug delivery system of low solubility drug for enhanced solubility and dissolution
Atorvastatin is a BCS class II lipid lowering agent. It is insoluble in aqueous solution of pH 4 and below; it is very slightly soluble in water and pH 7.4 phosphate buffer. In the present investigation an attempt has been made to enhance solubility and dissolution of poorly soluble drug by formulating self microemulsifying drug delivery system (SMEDDS). The solubility of atorvastatin in indivi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of ChemTech Research
سال: 2019
ISSN: 0974-4290,2455-9555
DOI: 10.20902/ijctr.2019.120520